DHEA is a hormone produced by the adrenal glands and serves as a precursor to male and female sex hormones.

It is used as a supplement for adrenal insufficiency, aging, and sometimes infertility.

Uses/Indications: Adrenal insufficiency, certain infertility cases, off-label for aging.

Precautions: May worsen hormone-sensitive cancers or mood disorders.

Contraindications: Pregnancy, breastfeeding, hormone-sensitive conditions.

Pregnenolone is a natural steroid hormone involved in the production of other hormones like progesterone and DHEA.

It is sometimes used for fatigue, memory, and hormone balance, though evidence is limited.

Uses/Indications: Fatigue, hormone support (off-label).

Precautions: May affect mood or hormone-sensitive conditions.

Contraindications: Pregnancy, breastfeeding.